It should not be used when there is a high risk of seizures (e.g., known ingestion of a drug associated with convulsions or mixed ingestion of unknown drugs).For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).Īctivity is based on recent site visitor activity relative to other medications in the list. It may be used with caution in patients with pure benzodiazepine poisoning who have severe respiratory depression and would otherwise require mechanical ventilation.įlumazenil should never be used as a diagnostic test and must only be administered by a clinician with expertise in its use. The risks associated with use of flumazenil, a benzodiazepine antagonist, outweigh any potential benefits for most patients. Acute management consists of maintaining airway, respiration, and haemodynamic support while excluding other diagnoses. The effects of benzodiazepines may be potentiated if taken in combination with other central nervous system (CNS) depressants, such as alcohol and opioids. Larger doses can cause coma, respiratory depression, and, without appropriate treatment, even death, particularly in the context of mixed ingestion with other CNS depressants. The key feature of overdose is excessive sedation.
Benzodiazepine overdose can be intentional (e.g., as an act of self-harm), as part of recreational misuse, or accidental (e.g., medication error).īenzodiazepines are the most commonly prescribed medications for anxiety, sedation, and sleep.
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